Multiple imputation for patient reported outcome measures in randomised controlled trials: advantages and disadvantages of imputing at the item, subscale or composite score level

<p>Background</p><p> Missing data can introduce bias in the results of randomised controlled trials (RCTs), but are typically unavoidable in pragmatic clinical research, especially when patient reported outcome measures (PROMs) are used. Traditionally applied to the composite PROM...

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Bibliographic Details
Main Authors: Rombach, I, Gray, A, Jenkinson, C, Murray, D, Rivero Arias, O
Format: Journal article
Published: BioMed Central 2018