BCL9L dysfunction impairs caspase-2 expression permitting aneuploidy tolerance in colorectal cancer.

Chromosomal instability (CIN) contributes to cancer evolution, intratumor heterogeneity, and drug resistance. CIN is driven by chromosome segregation errors and a tolerance phenotype that permits the propagation of aneuploid genomes. Through genomic analysis of colorectal cancers and cell lines, we...

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Bibliographic Details
Main Authors:	López-García, C, Sansregret, L, Domingo, E, McGranahan, N, Hobor, S, Birkbak, N, Horswell, S, Grönroos, E, Favero, F, Rowan, A, Matthews, N, Begum, S, Phillimore, B, Burrell, R, Oukrif, D, Spencer-Dene, B, Kovac, M, Stamp, G, Stewart, A, Danielsen, H, Novelli, M, Tomlinson, I, Swanton, C
Format:	Journal article
Language:	English
Published:	Elsevier 2017

BCL9L dysfunction impairs caspase-2 expression permitting aneuploidy tolerance in colorectal cancer.

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