Induction and transcriptional regulation of the co-inhibitory gene module in T cells

Expression of co-inhibitory receptors, such as CTLA-4 and PD-1, on effector T cells is a key mechanism for ensuring immune homeostasis. Dysregulated co-inhibitory receptor expression on CD4+ T cells promotes autoimmunity while sustained overexpression on CD8+ T cells promotes T cell dysfunction or e...

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Bibliographic Details
Main Authors:	Chihara, N, Madi, A, Kondo, T, Zhang, H, Acharya, N, Singer, M, Nyman, J, Marjanovic, N, Kowalczyk, MS, Wang, C, Kurtulus, S, Law, T, Etminan, Y, Nevin, J, Buckley, CD, Burkett, PR, Buenrostro, JD, Rozenblatt-Rosen, O, Anderson, AC, Regev, A, Kuchroo, VK
Format:	Journal article
Published:	Nature Publishing Group 2018

Induction and transcriptional regulation of the co-inhibitory gene module in T cells

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