Stereoselective preparation of lipidated carboxymethyl-proline/pipecolic acid derivatives via coupling of engineered crotonases with an alkylmalonyl-CoA synthetase.

Stereoselective preparation of lipidated carboxymethyl-proline/pipecolic acid derivatives via coupling of engineered crotonases with an alkylmalonyl-CoA synthetase.

The trisubstituted enolate- and C-C bond-forming capacities of engineered carboxymethylproline synthases CMPSs are coupled with the malonyl-CoA synthetase MatB to enable stereoselective preparation of 5- and 6-membered N-heterocycles functionalised with alkyl-substituted carboxymethyl side chains, s...

書誌詳細
主要な著者:	Hamed, R, Henry, L, Gomez-Castellanos, JR, Asghar, A, Brem, J, Claridge, T, Schofield, C
フォーマット:	Journal article
言語:	English
出版事項:	2013

類似資料

Use of methylmalonyl‐CoA epimerase in enhancing crotonase stereoselectivity
著者:: Hamed, R, 等
出版事項: (2015)

Crotonase catalysis enables flexible production of functionalized prolines and carbapenams.
著者:: Hamed, R, 等
出版事項: (2012)

Biocatalytic production of bicyclic β-lactams with three contiguous chiral centres using engineered crotonases
著者:: Hamed, R, 等
出版事項: (2019)

Crotonases: Nature’s exceedingly convertible catalysts
著者:: Lohans, C, 等
出版事項: (2017)

A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units
著者:: Lauren Ray, 等
出版事項: (2016-12-01)

Thioester hydrolysis and C-C bond formation by carboxymethylproline synthase from the crotonase superfamily.
著者:: Batchelar, E, 等
出版事項: (2008)

Mechanisms and structures of crotonase superfamily enzymes--how nature controls enolate and oxyanion reactivity.
著者:: Hamed, R, 等
出版事項: (2008)

Structural essentials for β-N-acetylhexosaminidase inhibition by amides of prolines, pipecolic and azetidine carboxylic acids
著者:: Glawar, A, 等
出版事項: (2016)

In Vitro Fertilisation of Mouse Oocytes in L-Proline and L-Pipecolic Acid Improves Subsequent Development
著者:: Tamara Treleaven, 等
出版事項: (2021-05-01)

Crystal structure of DmdD, a crotonase superfamily enzyme that catalyzes the hydration and hydrolysis of methylthioacryloyl-CoA.
著者:: Dazhi Tan, 等
出版事項: (2013-01-01)

Stereoselective production of dimethyl-substituted carbapenams via engineered carbapenem biosynthesis enzymes
著者:: Hamed, R, 等
出版事項: (2016)

Stereoselective C-C bond formation catalysed by engineered carboxymethylproline synthases.
著者:: Hamed, R, 等
出版事項: (2011)

Pyridoxine-Dependent Epilepsy and Pipecolic Acid
著者:: J Gordon Millichap
出版事項: (2000-07-01)

Carboxymethylproline synthase (CarB), an unusual carbon-carbon bond-forming enzyme of the crotonase superfamily involved in carbapenem biosynthesis.
著者:: Sleeman, M, 等
出版事項: (2004)

Studies on the selectivity of proline hydroxylases reveal new substrates including bicycles
著者:: Smart, TJ, 等
出版事項: (2019)

Stereoselective synthesis towards unnatural proline based amino acids
著者:: Sifiso S.Makhathini, 等
出版事項: (2016-02-01)

A concise and practical stereoselective synthesis of ipragliflozin L-proline
著者:: Shuai Ma, 等
出版事項: (2017-06-01)

An enzyme-coupled assay for acyl-CoA synthetase
出版事項: (1992-03-01)

Acetyl-CoA synthetase (ACSS2) does not generate butyryl- and crotonyl-CoA
著者:: Nour Zeaiter, 等
出版事項: (2024-03-01)

Pipecolic acid in plants: biosynthesis, signalling, and role under stress
著者:: Fatma Nur Koc, 等
出版事項: (2022-06-01)

Structural and mechanistic studies on carboxymethylproline synthase (CarB), a unique member of the crotonase superfamily catalyzing the first step in carbapenem biosynthesis.
著者:: Sleeman, M, 等
出版事項: (2005)

Letter-to-the-editor on “Acetyl-CoA synthetase (ACSS2) does not generate butyryl- and crotonyl-CoA”
著者:: Ting Xiang, 等
出版事項: (2024-05-01)

Characteristics of long‐chain acyl‐CoA synthetases in metabolism and cancer
著者:: Linlin Zhang, 等
出版事項: (2023-06-01)

Succinyl-CoA Synthetase: New Antigen Candidate of Bartonella bacilliformis.
著者:: Cláudia Gomes, 等
出版事項: (2016-09-01)

Pipecolic Acid Quantification Using Gas Chromatography-coupled Mass Spectrometry
著者:: Keshun Yu, 等
出版事項: (2020-12-01)

Response to letter-to-the-editor: “Acetyl-CoA synthetase (ACSS2) does not generate butyryl- and crotonyl-CoA”
著者:: Uwe Schlattner, 等
出版事項: (2024-05-01)

Mitochondrial Acetyl‐CoA Synthetase 3 is Biosignature of Gastric Cancer Progression
著者:: Wei‐Chun Chang, 等
出版事項: (2018-04-01)

Tomato Oxalyl-CoA Synthetase Degrades Oxalate and Affects Fruit Quality
著者:: Pengfei Li, 等
出版事項: (2022-07-01)

Organocatalytic enantioselective γ-aminoalkylation of unsaturated ester : access to pipecolic acid derivatives
著者:: Xu, Jianfeng, 等
出版事項: (2014)

Drought Shifts Sorghum Root Metabolite and Microbiome Profiles and Enriches for Pipecolic Acid
著者:: Daniel F. Caddell, 等
出版事項: (2023-12-01)

Regulation of Salicylic Acid and N-Hydroxy-Pipecolic Acid in Systemic Acquired Resistance
著者:: Gah-Hyun Lim
出版事項: (2023-02-01)

Syntaxin 17 promotes lipid droplet formation by regulating the distribution of acyl-CoA synthetase 3[S]
著者:: Hana Kimura, 等
出版事項: (2018-01-01)

Acetyl-CoA synthetase activity is enzymatically regulated by lysine acetylation using acetyl-CoA or acetyl-phosphate as donor molecule
著者:: Chuan Qin, 等
出版事項: (2024-07-01)

Using the pimeloyl-CoA synthetase adenylation fold to synthesize fatty acid thioesters
著者:: Wang, M, 等
出版事項: (2017)

Entamoeba histolytica acetyl-CoA synthetase: biomarker of acute amoebic liver abscess
著者:: Lim, Boon Huat, 等
出版事項: (2014)

Acyl-CoA Synthetase 5 Promotes the Growth and Invasion of Colorectal Cancer Cells
著者:: Shihua Ding, 等
出版事項: (2017-01-01)

Activation of acetyl-CoA synthetase 2 mediates kidney injury in diabetic nephropathy
著者:: Jian Lu, 等
出版事項: (2023-10-01)

Modulation of plant acetyl-CoA synthetase activity by post-translational lysine acetylation
著者:: Naazneen Sofeo, 等
出版事項: (2023-03-01)

Entamoeba histolytica acetyl–CoA synthetase: biomarker of acute amoebic liver abscess
著者:: Lim Boon Huat, 等
出版事項: (2014-06-01)

An acyl-CoA synthetase in Mycobacterium tuberculosis involved in triacylglycerol accumulation during dormancy.
著者:: Jaiyanth Daniel, 等
出版事項: (2014-01-01)