Defining therapeutic targets by using adenovirus: blocking NF-kappaB inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares anti-inflammatory mediators.

Detaylı Bibliyografya
Asıl Yazarlar:	Bondeson, J, Foxwell, B, Brennan, F, Feldmann, M
Materyal Türü:	Journal article
Dil:	English
Baskı/Yayın Bilgisi:	1999

NF-kappaB-inducing kinase is dispensable for activation of NF-kappaB in inflammatory settings but essential for lymphotoxin beta receptor activation of NF-kappaB in primary human fibroblasts.
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Baskı/Yayın Bilgisi: (2001)

Is NF-kappaB a useful therapeutic target in rheumatoid arthritis?
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Efficient adenoviral infection with IkappaB alpha reveals that macrophage tumor necrosis factor alpha production in rheumatoid arthritis is NF-kappaB dependent.
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VEGF expression in human macrophages is NF-kappaB-dependent: studies using adenoviruses expressing the endogenous NF-kappaB inhibitor IkappaBalpha and a kinase-defective form of the IkappaB kinase 2.
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Effective adenoviral transfer of IkappaBalpha into human fibroblasts and chondrosarcoma cells reveals that the induction of matrix metalloproteinases and proinflammatory cytokines is nuclear factor-kappaB dependent.
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Analysis of cytokine expression in rheumatoid synovium has provided new insights into the pathogenesis of rheumatoid arthritis and new therapeutic opportunities.
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Cell-Type Targeted NF-kappaB Inhibition for the Treatment of Inflammatory Diseases
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Selective regulation of cytokine induction by adenoviral gene transfer of IkappaBalpha into human macrophages: lipopolysaccharide-induced, but not zymosan-induced, proinflammatory cytokines are inhibited, but IL-10 is nuclear factor-kappaB independent.
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Alveolar macrophages and T cells from sarcoid, but not normal lung, are permissive to adenovirus infection and allow analysis of NF-kappa b-dependent signaling pathways.
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TREM-1 expression is increased in the Synovium of Rheumatoid Arthritis patients and induces the expression of pro-inflammatory cytokines
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JNK pathway is involved in the inhibition of inflammatory target gene expression and NF-kappaB activation by melittin
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Evidence that rheumatoid arthritis synovial T cells are similar to cytokine-activated T cells: involvement of phosphatidylinositol 3-kinase and nuclear factor kappaB pathways in tumor necrosis factor alpha production in rheumatoid arthritis.
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Foxp3 represses retroviral transcription by targeting both NF-kappaB and CREB pathways.
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Addressing reported pro-apoptotic functions of NF-kappaB: targeted inhibition of canonical NF-kappaB enhances the apoptotic effects of doxorubicin.
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Fufang-Zhenzhu-Tiaozhi Capsule reduces restenosis via the downregulation of NF-kappaB and inflammatory factors in rabbits
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TREM-1 expression is increased in the synovium of rheumatoid arthritis patients and induces the expression of pro-inflammatory cytokines.
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Visualization of lymphatic vessels through NF-kappaB activity.
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The flavonoid luteolin worsens chemical-induced colitis in NF-kappaB(EGFP) transgenic mice through blockade of NF-kappaB-dependent protective molecules.
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Effects of Xuefu Zhuyu Decoction on Inflammatory Factors and the NF-kappaB Signaling Pathway in Rats Model of Radicular Pain
Yazar:: Liu X, ve diğerleri
Baskı/Yayın Bilgisi: (2025-02-01)

Inhibition of NF-kappaB enhances the cytotoxicity of virus-directed enzyme prodrug therapy and oncolytic adenovirus cancer gene therapy.
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The role of NF-kappaB in the inflammatory processes related to dental caries, pulpitis, apical periodontitis, and periodontitis–a narrative review
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Baskı/Yayın Bilgisi: (2024-08-01)

Myelin activates FAK/Akt/NF-kappaB pathways and provokes CR3-dependent inflammatory response in murine system.
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Haploid reporter screens aimed at identification of NF-kappaB regulators
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Memory extinction entails the inhibition of the transcription factor NF-kappaB.
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NF-kappaB/Rel-mediated regulation of the neural fate in Drosophila.
Yazar:: Savita Ayyar, ve diğerleri
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Defining therapeutic targets by using adenovirus: blocking NF-kappaB inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares anti-inflammatory mediators.

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