Global N-glycan site occupancy of HIV-1 gp120 by metabolic engineering and high-resolution intact mass spectrometry

A vital step in HIV vaccine development strategies has been the observation that some infected individuals generate broadly neutralizing antibodies that target the glycans on the surface of HIV-1 gp120. These antibodies target glycan epitopes on viral envelope spikes and yet the positions and degre...

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Bibliographic Details
Main Authors: Struwe, W, Stuckmann, A, Behrens, A, Pagel, K, Crispin, M
Format: Journal article
Published: American Chemical Society 2016