Evaluation of the safety and immunogenicity of a candidate tuberculosis vaccine, MVA85A, delivered by aerosol to the lungs of macaques.

Tuberculosis (TB) is a reemerging disease. The only available vaccine, Mycobacterium bovis BCG, is delivered intradermally and confers highly variable efficacy against pulmonary disease. There is an urgent need for improved vaccination strategies. Murine studies suggest that immunizations delivered...

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Hlavní autoři: White, A, Sibley, L, Dennis, M, Gooch, K, Betts, G, Edwards, N, Reyes-Sandoval, A, Carroll, M, Williams, A, Marsh, P, McShane, H, Sharpe, SA
Médium: Journal article
Jazyk:English
Vydáno: 2013