Psoriatic T cells recognize neolipid antigens generated by mast cell phospholipase delivered by exosomes and presented by CD1a

Psoriasis is a chronic inflammatory skin disease associated with a T helper 17 response. Yet, it has proved challenging to identify relevant peptide-based T cell antigens. Antigen-presenting Langerhans cells show a differential migration phenotype in psoriatic lesions and express constitutively high...

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Bibliographic Details
Main Authors: Cheung, K, Jarrett, R, Subramaniam, S, Salimi, M, Gutowska-Owsiak, D, Chen, Y, Hardman, C, Xue, L, Cerundolo, V, Ogg, G
Format: Journal article
Published: Rockefeller University Press 2016