Structural and functional characterization of the human protein kinase ASK1.

Structural and functional characterization of the human protein kinase ASK1.

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Apoptosis signal-regulating kinase 1 (ASK1) plays an essential role in stress and immune response and has been linked to the development of several diseases. Here, we present the structure of the human ASK1 catalytic domain in complex with staurosporine. Analytical ultracentrifugation (AUC) and crys...

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Detalles Bibliográficos
Autores principales: Bunkoczi, G, Salah, E, Filippakopoulos, P, Fedorov, O, Müller, S, Sobott, F, Parker, S, Zhang, H, Min, W, Turk, B, Knapp, S
Formato: Journal article
Lenguaje:English
Publicado: 2007
Materias:
Enzyme Inhibitors
Amino Acid Sequence
chemistry
Humans
Staurosporine
Models, Molecular
Molecular Sequence Data
Phosphorylation
Binding Sites
Protein Conformation
MAP Kinase Kinase Kinase 5
Catalysis
metabolism
Protein Structure, Tertiary
Dimerization
Substrate Specificity
Enzyme Activation
Structure-Activity Relationship

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