Silencing of ASXL1 impairs the granulomonocytic lineage potential of human CD34⁺ progenitor cells.
The ASXL1 gene encodes a chromatin-binding protein involved in epigenetic regulation in haematopoietic cells. Loss-of-function ASXL1 mutations occur in patients with a range of myeloid malignancies and are associated with adverse outcome. We have used lentiviral-based shRNA technology to investigate...
Հիմնական հեղինակներ: | Davies, C, Yip, B, Fernandez-Mercado, M, Woll, P, Agirre, X, Prosper, F, Jacobsen, SE, Wainscoat, J, Pellagatti, A, Boultwood, J |
---|---|
Ձևաչափ: | Journal article |
Լեզու: | English |
Հրապարակվել է: |
2013
|
Նմանատիպ նյութեր
-
Silencing of ASXL1 impairs the granulomonocytic lineage potential of human CD34+ progenitor cells
: Davies, C, և այլն
Հրապարակվել է: (2013) -
Frequent Mutation of the Polycomb-Associated Gene ASXL1 In Acute Myeloid Leukemia Secondary to Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia
: Fernandez-Mercado, M, և այլն
Հրապարակվել է: (2010) -
Frequent Mutation of the Polycomb-Associated Gene ASXL1 in the Myelodysplastic Syndromes and in Acute Myeloid Leukaemia
: Boultwood, J, և այլն
Հրապարակվել է: (2009) -
Frequent mutation of the polycomb-associated gene ASXL1 in the myelodysplastic syndromes and in acute myeloid leukemia.
: Boultwood, J, և այլն
Հրապարակվել է: (2010) -
High-density single nucleotide polymorphism array analysis and ASXL1 gene mutation screening in chronic myeloid leukemia during disease progression.
: Boultwood, J, և այլն
Հրապարակվել է: (2010)