Structural flexibility of the macrophage dengue virus receptor CLEC5A: implications for ligand binding and signaling.

The human C-type lectin-like molecule CLEC5A is a critical macrophage receptor for dengue virus. The binding of dengue virus to CLEC5A triggers signaling through the associated adapter molecule DAP12, stimulating proinflammatory cytokine release. We have crystallized an informative ensemble of CLEC5...

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Bibliographic Details
Main Authors:	Watson, A, Lebedev, A, Hall, B, Fenton-May, A, Vagin, A, Dejnirattisai, W, Felce, J, Mongkolsapaya, J, Palma, A, Liu, Y, Feizi, T, Screaton, G, Murshudov, G, O'Callaghan, C
Format:	Journal article
Language:	English
Published:	2011

Structural flexibility of the macrophage dengue virus receptor CLEC5A: implications for ligand binding and signaling.

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