TCR–pMHC kinetics under force in a cell-free system show no intrinsic catch bond, but a minimal encounter duration before binding

The T cell receptor (TCR)–peptide-MHC (pMHC) interaction is the only antigen-specific interaction during T lymphocyte activation. Recent work suggests that formation of catch bonds is characteristic of activating TCR–pMHC interactions. However, whether this binding behavior is an intrinsic feature o...

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Những tác giả chính: Limozin, L, Bridge, M, Bongrand, P, Dushek, O, Van Der Merwe, P, Robert, P
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: National Academy of Sciences 2019

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