TCR–pMHC kinetics under force in a cell-free system show no intrinsic catch bond, but a minimal encounter duration before binding
The T cell receptor (TCR)–peptide-MHC (pMHC) interaction is the only antigen-specific interaction during T lymphocyte activation. Recent work suggests that formation of catch bonds is characteristic of activating TCR–pMHC interactions. However, whether this binding behavior is an intrinsic feature o...
Những tác giả chính: | Limozin, L, Bridge, M, Bongrand, P, Dushek, O, Van Der Merwe, P, Robert, P |
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Định dạng: | Journal article |
Ngôn ngữ: | English |
Được phát hành: |
National Academy of Sciences
2019
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