Orchestrated control of filaggrin–actin scaffolds underpins cornification

Epidermal stratification critically depends on keratinocyte differentiation and programmed death by cornification, leading to formation of a protective skin barrier. Cornification is dynamically controlled by the protein filaggrin, rapidly released from keratohyalin granules (KHGs). However, the mec...

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Bibliographic Details
Main Authors: Gutowska-Owsiak, D, de La Serna, J, Fritzsche, M, Naeem, A, Podobas, E, Leeming, M, Colin-York, H, O'Shaughnessy, R, Eggeling, C, Ogg, G
Format: Journal article
Published: Nature Publishing Group 2018