Biosynthesis of histone messenger RNA employs a specific 3' end endonuclease

Replication-dependent (RD) core histone mRNA produced during S-phase is the only known metazoan protein-coding mRNA presenting a 3' stem-loop instead of the otherwise universal polyA tail. A metallo β-lactamase (MBL) fold enzyme, cleavage and polyadenylation specificity factor 73 (CPSF73), is p...

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Bibliographic Details
Main Authors: Pettinati, I, Grzechnik, P, Ribeiro De Almeida, C, Brem, J, McDonough, M, Dhir, S, Proudfoot, N, Schofield, C
Format: Journal article
Language:English
Published: eLife Sciences Publications 2018