HLA variants have different preferences to present proteins with specific molecular functions which are complemented in frequent haplotypes

<p>Human leukocyte antigen (HLA) genes are the most polymorphic loci in the human genome and code for proteins that play a key role in guiding adaptive immune responses by presenting foreign and self peptides (ligands) to T cells. Each person carries up to 6 HLA class I variants (maternal and...

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Bibliographic Details
Main Authors: Karnaukhov, V, Paes, W, Woodhouse, IB, Partridge, T, Nicastri, A, Brackenridge, S, Ternette, N, Koohy, H, Borrow, P
Format: Journal article
Language:English
Published: Frontiers Media 2022