Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay.

The activity and levels of the metazoan HIF (hypoxia-inducible factor) are regulated by its hydroxylation, catalysed by 2OG (2-oxoglutarate)- and Fe(II)-dependent dioxygenases. An oxygen consumption assay was developed and used to study the relationship between HIF hydroxylase activity and oxygen co...

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Príomhchruthaitheoirí: Ehrismann, D, Flashman, E, Genn, D, Mathioudakis, N, Hewitson, K, Ratcliffe, P, Schofield, C
Formáid: Journal article
Teanga:English
Foilsithe / Cruthaithe: 2007