Calbindin-D28K limits dopamine release in ventral but not dorsal striatum by regulating Ca2+ availability and dopamine transporter function

The calcium-binding protein calbindin-D28K, or calb1, is expressed at higher levels by dopamine (DA) neurons originating in ventral tegmental area (VTA) than in adjacent substantia nigra pars compacta (SNc). Calb1 has received attention for a potential role in neuroprotection in Parkinson’s disease....

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Bibliographic Details
Main Authors: Brimblecombe, K, Vietti-Michelina, S, Platt, N, Kastli, R, Hnieno, A, Gracie, C, Cragg, S
Format: Journal article
Language:English
Published: American Chemical Society 2019