Using functional and computational genomics approaches to study the cross-talk between radiosensitivity and HIF-1α activation
<p>Radiotherapy is believed to account for 40% of curative cancer treatment, yet ionising radiation (IR) resistance often ensues. Hypoxia, accompanied by HIF-1α pathway activation, is a known IR resistance mechanism. Studies have revealed ubiquitination’s crucial roles in DNA damage response a...
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| Format: | Thesis |
| Language: | English |
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2023
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