Bosentan alleviates the pro-fibrotic phenotype of lung scleroderma fibroblasts: Implications for treatment of scleroderma.

Bosentan alleviates the pro-fibrotic phenotype of lung scleroderma fibroblasts: Implications for treatment of scleroderma.

Manylion Llyfryddiaeth
Prif Awduron:	Leask, A, Xu, S, Renzoni, E, Bou-Gharios, G, du Bois, R, Abraham, D, Black, C
Fformat:	Conference item
Cyhoeddwyd:	2005

Eitemau Tebyg

Bosentan attenuates the profibrotic gene expression profile of lung fibroblasts in scleroderma
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Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts.
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