External validation of clinical prediction models: simulation-based sample size calculations were more reliable than rules-of-thumb

<br><strong>Introduction<br></strong> Sample size “rules-of-thumb” for external validation of clinical prediction models suggest at least 100 events and 100 non-events. Such blanket guidance is imprecise, and not specific to the model or validation setting. We investigate fac...

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Bibliographic Details
Main Authors: Snell, KIE, Archer, L, Ensor, J, Bonnett, LJ, Debray, TPA, Phillips, B, Collins, GS, Riley, RD
Format: Journal article
Language:English
Published: Elsevier 2021