Evaluation of computational modelling as a preclinical proarrhythmic safety assay

Many cardiac ion channels are prone to reduced current flow following blockade by pharmaceutical compounds. High throughput screening technologies now allow us to establish this reduction in activity routinely and relatively cheaply. It would be advantageous to integrate this information to provide...

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Bibliographic Details
Main Authors: Mirams, G, Beattie, K, Cui, Y, Luscombe, C, Williams, G, Gavaghan, D, McMahon, N
Format: Conference item
Published: 2013