The structural basis of immune receptor signalling
This work investigates the mechanisms of binding of T cell receptors (TCRs) to Class I MHC-peptide complexes (pMHC). The structure of a TCR specific for the Melan-A tumour antigen bound to its cognate pMHC was solved to a resolution of 2.5 Å which gives insight into how this TCR could be mutated to...
Главные авторы: | , |
---|---|
Другие авторы: | |
Формат: | Диссертация |
Язык: | English |
Опубликовано: |
2008
|
Предметы: |