Glypicans shield the Wnt lipid moiety to enable signalling at a distance

A relatively small number of proteins have been suggested to act as morphogens—signalling molecules that spread within tissues to organize tissue repair and the specification of cell fate during development. Among them are Wnt proteins, which carry a palmitoleate moiety that is essential for signall...

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Bibliographic Details
Main Authors: McGough, IJ, Vecchia, L, Bishop, B, Malinauskas, T, Beckett, K, Joshi, D, O'Reilly, N, Siebold, C, Jones, EY, Vincent, J-P
Format: Journal article
Language:English
Published: Nature Research 2020