Maximum-likelihood estimation of the statistical distribution of Smith-Waterman local sequence similarity scores.
A method is described for estimating the distribution and hence testing the statistical significance of sequence similarity scores obtained during a data-bank search. Maximum-likelihood is used to fit a model to the scores, avoiding any costly simulation of random sequences. The method is applied in...
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| Format: | Journal article |
| Language: | English |
| Published: |
1992
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