Lack of a significant adverse cardiovascular effect of combined quinine and mefloquine therapy for uncomplicated malaria.
Quinine dihydrochloride (10 mg salt/kg infused over one hour) and mefloquine (15 mg base/kg) were given simultaneously to 13 adults with uncomplicated falciparum malaria. Supine and standing blood pressures were recorded and the electrocardiogram monitored. Plasma concentrations of the 2 drugs were...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1997
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| _version_ | 1797061832992620544 |
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| author | Supanaranond, W Suputtamongkol, Y Davis, T Pukrittayakamee, S Teja-Isavadharm, P Webster, H White, N |
| author_facet | Supanaranond, W Suputtamongkol, Y Davis, T Pukrittayakamee, S Teja-Isavadharm, P Webster, H White, N |
| author_sort | Supanaranond, W |
| collection | OXFORD |
| description | Quinine dihydrochloride (10 mg salt/kg infused over one hour) and mefloquine (15 mg base/kg) were given simultaneously to 13 adults with uncomplicated falciparum malaria. Supine and standing blood pressures were recorded and the electrocardiogram monitored. Plasma concentrations of the 2 drugs were similar to those reported previously for the 2 compounds given individually to a similar group of patients. Although postural hypotension was common (6 cases before treatment and 7 after) and the electrocardiogram QTc interval was prolonged by a mean of 12% (SD = 8) following drug treatment, there was no evidence of a clinically significant cardiovascular pharmacodynamic interaction between these 2 structurally related antimalarial compounds. |
| first_indexed | 2024-03-06T20:36:48Z |
| format | Journal article |
| id | oxford-uuid:32eb59ea-e8a6-4287-8389-db7b915225e8 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:36:48Z |
| publishDate | 1997 |
| record_format | dspace |
| spelling | oxford-uuid:32eb59ea-e8a6-4287-8389-db7b915225e82022-03-26T13:17:01ZLack of a significant adverse cardiovascular effect of combined quinine and mefloquine therapy for uncomplicated malaria.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:32eb59ea-e8a6-4287-8389-db7b915225e8EnglishSymplectic Elements at Oxford1997Supanaranond, WSuputtamongkol, YDavis, TPukrittayakamee, STeja-Isavadharm, PWebster, HWhite, NQuinine dihydrochloride (10 mg salt/kg infused over one hour) and mefloquine (15 mg base/kg) were given simultaneously to 13 adults with uncomplicated falciparum malaria. Supine and standing blood pressures were recorded and the electrocardiogram monitored. Plasma concentrations of the 2 drugs were similar to those reported previously for the 2 compounds given individually to a similar group of patients. Although postural hypotension was common (6 cases before treatment and 7 after) and the electrocardiogram QTc interval was prolonged by a mean of 12% (SD = 8) following drug treatment, there was no evidence of a clinically significant cardiovascular pharmacodynamic interaction between these 2 structurally related antimalarial compounds. |
| spellingShingle | Supanaranond, W Suputtamongkol, Y Davis, T Pukrittayakamee, S Teja-Isavadharm, P Webster, H White, N Lack of a significant adverse cardiovascular effect of combined quinine and mefloquine therapy for uncomplicated malaria. |
| title | Lack of a significant adverse cardiovascular effect of combined quinine and mefloquine therapy for uncomplicated malaria. |
| title_full | Lack of a significant adverse cardiovascular effect of combined quinine and mefloquine therapy for uncomplicated malaria. |
| title_fullStr | Lack of a significant adverse cardiovascular effect of combined quinine and mefloquine therapy for uncomplicated malaria. |
| title_full_unstemmed | Lack of a significant adverse cardiovascular effect of combined quinine and mefloquine therapy for uncomplicated malaria. |
| title_short | Lack of a significant adverse cardiovascular effect of combined quinine and mefloquine therapy for uncomplicated malaria. |
| title_sort | lack of a significant adverse cardiovascular effect of combined quinine and mefloquine therapy for uncomplicated malaria |
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