Truncation of Kir6.2 produces ATP-sensitive K+ channels in the absence of the sulphonylurea receptor.

Truncation of Kir6.2 produces ATP-sensitive K+ channels in the absence of the sulphonylurea receptor.

ATP-sensitive potassium channels (K-ATP channels) couple cell metabolism to electrical activity and are important in the physiology and pathophysiology of many tissues. In pancreatic beta-cells, K-ATP channels link changes in blood glucose concentration to insulin secretion. They are also the target...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Tucker, S, Gribble, F, Zhao, C, Trapp, S, Ashcroft, F
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	1997

Παρόμοια τεκμήρια

Interaction of MgATP with the sulphonylurea subunit activates ATP sensitive K-channels receptor
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Involvement of the n-terminus of Kir6.2 in coupling to the sulphonylurea receptor.
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Involvement of the N-terminus of Kir6.2 in the inhibition of the KATP channel by ATP.
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The role of lysine 185 in the kir6.2 subunit of the ATP-sensitive channel in channel inhibition by ATP.
ανά: Reimann, F, κ.ά.
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Analysis of the differential modulation of sulphonylurea block of beta-cell and cardiac ATP-sensitive K+ (K(ATP)) channels by Mg-nucleotides.
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Nucleotide modulation of pinacidil stimulation of the cloned K(ATP) channel Kir6.2/SUR2A.
ανά: Gribble, F, κ.ά.
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Direct photoaffinity labeling of the Kir6.2 subunit of the ATP-sensitive K+ channel by 8-azido-ATP.
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Glimepiride block of Kir6.2/SUR1 Kir6.2/SUR2A and Kir6.2/SUR2A and Kir6.2/SUR2B K-ATP channels.
ανά: Ashcroft, F, κ.ά.
Έκδοση: (2001)

Expression of truncated Kir6.2 promotes insertion of functionally inverted ATP-sensitive K+ channels
ανά: Benjamin A. Heitz, κ.ά.
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A model for regulation of the beta-cell ATP-sensitive K+-channel by nucleotides and diazoxide.
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Mechanism of K-ATP channel inhibition by ATP
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Έκδοση: (1998)

Identification of residues contributing to the ATP binding site of Kir6.2.
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Time-dependent activation of Kir6.2/SUR2A channels but not Kir6.2/SUR1 channels in the presence of ATP
ανά: Ashcroft, F, κ.ά.
Έκδοση: (2001)

Interaction of the cytosolic domains of the Kir6.2 subunit of the K(ATP) channel is modulated by sulfonylureas.
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Effects of mitiglinide (S 21403) on Kir6.2/SUR1, Kir6.2/SUR2A and Kir6.2/SUR2B types of ATP-sensitive potassium channel.
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Time-dependent activation of KIR6.2/SUR2A channels but not KIR6.2/SUR1 channels in the presence of MgATP
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A novel SUR1/Kir6.2 specific K-ATP channel opener
ανά: Dabrowski, M, κ.ά.
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Behavioral phenotyping of mice lacking the K ATP channel subunit Kir6.2.
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Έκδοση: (2006)

Behavioral phenotyping of mice lacking the K ATP channel subunit Kir6.2.
ανά: Deacon, R, κ.ά.
Έκδοση: (2006)

Focus on Kir6.2: a key component of the ATP-sensitive potassium channel.
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Έκδοση: (2005)

Molecular analysis of ATP-sensitive K channel gating and implications for channel inhibition by ATP.
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Phentolamine block of ATP-sensitive K+ channels does not involve interaction with the sulphonylurea receptor, SUR1.
ανά: Proks, P, κ.ά.
Έκδοση: (1997)

Mechanism of ATP-sensitive K channel inhibition by sulfhydryl modification.
ανά: Trapp, S, κ.ά.
Έκδοση: (1998)

Kir6.2-dependent high-affinity repaglinide binding to beta-cell K(ATP) channels.
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Έκδοση: (2005)

Mapping the architecture of the ATP-binding site of the KATP channel subunit Kir6.2.
ανά: Dabrowski, M, κ.ά.
Έκδοση: (2004)

Mapping the architecture of the ATP-binding site of Kir6.2
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Gating and ATP-sensitivity of the cloned beta-cell K-ATP channel
ανά: Trapp, S, κ.ά.
Έκδοση: (1998)

The sulphonylurea receptor confers diazoxide sensitivity on the inwardly rectifying K+ channel Kir6.1 expressed in human embryonic kidney cells.
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Έκδοση: (1996)

Molecular mechanism of sulphonylurea block of K(ATP) channels carrying mutations that impair ATP inhibition and cause neonatal diabetes.
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Έκδοση: (2013)

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Correlating structure and function in ATP-sensitive K+ channels.
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Mutations within the P-loop of Kir6.2 modulate the intraburst kinetics of the ATP-sensitive potassium channel.
ανά: Proks, P, κ.ά.
Έκδοση: (2001)

Overlapping distribution of K(ATP) channel-forming Kir6.2 subunit and the sulfonylurea receptor SUR1 in rodent brain.
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Έκδοση: (1997)

Pyridine nucleotide regulation of the KATP channel Kir6.2/SUR1 expressed in Xenopus oocytes.
ανά: Dabrowski, M, κ.ά.
Έκδοση: (2003)

The Kir6.2-F333I mutation differentially modulates K-ATP channels composed of SUR1 or SUR2 subunits
ανά: Tammaro, P, κ.ά.
Έκδοση: (2007)

The Kir6.2-F333I mutation differentially modulates K ATP channels composed of SUR1 and SUR2 subunits
ανά: Tammaro, P, κ.ά.
Έκδοση: (2007)

ATP-dependent interaction of the cytosolic domains of the inwardly rectifying K+ channel Kir6.2 revealed by fluorescence resonance energy transfer.
ανά: Tsuboi, T, κ.ά.
Έκδοση: (2004)

Thiol reagents and ATP do not interact with C717 in the SUR1 subunit of the beta-cell K-ATP channel
ανά: Trapp, S, κ.ά.
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Structure-function studies of the fast gating kinetics of the cloned ATP-sensitive potassium channel, Kir6.2/SUR1
ανά: Proks, P, κ.ά.
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