Design, synthesis and structure-activity relationships of 3,5-diaryl-1H-pyrazoles as inhibitors of arylamine N-acetyltransferase.

The synthesis and inhibitory potencies of a novel series of 3,5-diaryl-1H-pyrazoles as specific inhibitors of prokaryotic arylamine N-acetyltransferase enzymes is described. The series is based on hit compound 1 3,5-diaryl-1H-pyrazole identified from a high-throughout screen that has been carried ou...

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Bibliografische gegevens
Hoofdauteurs: Fullam, E, Talbot, J, Abuhammed, A, Westwood, I, Davies, S, Russell, A, Sim, E
Formaat: Journal article
Taal:English
Gepubliceerd in: 2013