Distinct immune cell infiltration patterns in pancreatic ductal adenocarcinoma (PDAC) exhibit divergent immune cell selection and immunosuppressive mechanisms

Pancreatic ductal adenocarcinoma has a dismal prognosis. A comprehensive analysis of single-cell multi-omic data from matched tumour-infiltrated CD45+ cells and peripheral blood in 12 patients, and two published datasets, reveals a complex immune infiltrate. Patients have either a myeloid-enriched o...

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Bibliographic Details
Main Authors:	Sivakumar, S, Jainarayanan, A, Arbe-Barnes, E, Sharma, PK, Leathlobhair, MN, Amin, S, Reiss, DJ, Heij, L, Hegde, S, Magen, A, Tucci, F, Sun, B, Wu, S, Anand, NM, Slawinski, H, Revale, S, Nassiri, I, Webber, J, Hoeltzel, GD, Frampton, AE, Wiltberger, G, Neumann, U, Charlton, P, Spiers, L, Elliott, T, Middleton, MR, Peppa, D, Fairfax, B, Dustin, ML, Abu-Shah, E, Bashford-Rogers, R
Format:	Journal article
Language:	English
Published:	Nature Research 2025

Distinct immune cell infiltration patterns in pancreatic ductal adenocarcinoma (PDAC) exhibit divergent immune cell selection and immunosuppressive mechanisms

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