Arylsulfonamide inhibitors of aggrecanases as potential therapeutic agents for osteoarthritis: synthesis and biological evaluation.

Aggrecanases, in particular aggrecanase-2 (ADAMTS-5), are considered the principal proteases responsible for aggrecan degradation in osteoarthritis. For this reason, considerable effort has been put on the discovery and development of aggrecanase inhibitors able to slow down or halt the progression...

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Bibliografski detalji
Glavni autori: Nuti, E, Santamaria, S, Casalini, F, Yamamoto, K, Marinelli, L, La Pietra, V, Novellino, E, Orlandini, E, Nencetti, S, Marini, A, Salerno, S, Taliani, S, Da Settimo, F, Nagase, H, Rossello, A
Format: Journal article
Jezik:English
Izdano: 2013