LRP-1-mediated endocytosis regulates extracellular activity of ADAMTS-5 in articular cartilage.

LRP-1-mediated endocytosis regulates extracellular activity of ADAMTS-5 in articular cartilage.

Aggrecan is a major matrix component of articular cartilage, and its degradation is a crucial event in the development of osteoarthritis (OA). Adamalysin-like metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) is a major aggrecan-degrading enzyme in cartilage, but there is no clear correlatio...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	Yamamoto, K, Troeberg, L, Scilabra, S, Pelosi, M, Murphy, C, Strickland, D, Nagase, H
Формат:	Journal article
Хэл сонгох:	English
Хэвлэсэн:	2013

Ижил төстэй зүйлс

Low density lipoprotein receptor-related protein 1 (LRP1)-mediated endocytic clearance of a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4): functional differences of non-catalytic domains of ADAMTS-4 and ADAMTS-5 in LRP1 binding.
-н: Yamamoto, K, зэрэг
Хэвлэсэн: (2014)

LRP-dependent and -independent internalisation of TIMP-3
-н: Scilabra, S, зэрэг
Хэвлэсэн: (2011)

Inhibition of LRP1 shedding reverses cartilage matrix degradation in osteoarthritis
-н: Yamamoto, K, зэрэг
Хэвлэсэн: (2017)

MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1
-н: Yamamoto, K, зэрэг
Хэвлэсэн: (2016)

The C-terminal domains of ADAMTS-4 and ADAMTS-5 promote association with N-TIMP-3.
-н: Troeberg, L, зэрэг
Хэвлэсэн: (2009)

Cilia protein IFT88 regulates extracellular protease activity by optimizing LRP-1–mediated endocytosis
-н: Coveney, C, зэрэг
Хэвлэсэн: (2018)

Development of a monoclonal anti-ADAMTS-5 antibody that specifically blocks the interaction with LRP1
-н: Santamaria, S, зэрэг
Хэвлэсэн: (2017)

Involvement of ADAMTS5 and hyaluronidase in aggrecan degradation and release from OSM-stimulated cartilage.
-н: Durigova, M, зэрэг
Хэвлэсэн: (2011)

Involvement of ADAMTS5 and hyaluronidase in aggrecan degradation and release from OSM-stimulated cartilage
-н: M Durigova, зэрэг
Хэвлэсэн: (2011-01-01)

Differential regulation of extracellular tissue inhibitor of metalloproteinases-3 levels by cell membrane-bound and shed low density lipoprotein receptor-related protein 1.
-н: Scilabra, S, зэрэг
Хэвлэсэн: (2013)

Hemoglobin stimulates the expression of ADAMTS-5 and ADAMTS-9 by synovial cells: a possible cause of articular cartilage damage after intra-articular hemorrhage
-н: Takuya Tajima, зэрэг
Хэвлэсэн: (2017-11-01)

Functional differences of the catalytic and non-catalytic domains in human ADAMTS-4 and ADAMTS-5 in aggrecanolytic activity.
-н: Fushimi, K, зэрэг
Хэвлэсэн: (2008)

Investigation of the endocytic pathway of ADAMTS-4
-н: Owen, K, зэрэг
Хэвлэсэн: (2009)

Characterization of an ADAMTS-5-mediated cleavage site in aggrecan in OSM-stimulated bovine cartilage.
-н: Durigova, M, зэрэг
Хэвлэсэн: (2008)

The matricellular receptor LRP1 forms an interface for signaling and endocytosis in modulation of the extracellular tumor environment
-н: Bart eVan Gool, зэрэг
Хэвлэсэн: (2015-11-01)

Calcium pentosan polysulfate increases affinity between aggrecanases (ADAMTS-4 and-5) and TIMP-3 by a conformational change
-н: Troeberg, L, зэрэг
Хэвлэсэн: (2010)

Engineered tissue inhibitor of metalloproteinases-3 variants resistant to endocytosis have prolonged chondroprotective activity
-н: Doherty, C, зэрэг
Хэвлэсэн: (2016)

Dissecting the interaction between tissue inhibitor of metalloproteinases-3 (TIMP-3) and low density lipoprotein receptor-related protein-1 (LRP-1): Development of a "TRAP" to increase levels of TIMP-3 in the tissue.
-н: Scilabra, S, зэрэг
Хэвлэсэн: (2016)

JNK2 controls aggrecan degradation in murine articular cartilage and the development of experimental osteoarthritis.
-н: Ismail, H, зэрэг
Хэвлэсэн: (2015)

The interplay between JNK pathway activation, proteoglycan turnover and endocytosis in chondrocytes
-н: Ismail, H, зэрэг
Хэвлэсэн: (2017)

Pentosan polysulfate increases affinity between ADAMTS-5 and TIMP-3 through formation of an electrostatically driven trimolecular complex
-н: Troeberg, L, зэрэг
Хэвлэсэн: (2012)

Pentosan polysulfate increases affinity between ADAMTS-5 and TIMP-3 through formation of an electrostatically driven trimolecular complex.
-н: Troeberg, L, зэрэг
Хэвлэсэн: (2012)

Proteases involved in cartilage matrix degradation in osteoarthritis.
-н: Troeberg, L, зэрэг
Хэвлэсэн: (2012)

Clathrin and LRP-1-independent constitutive endocytosis and recycling of uPAR.
-н: Katia Cortese, зэрэг
Хэвлэсэн: (2008-01-01)

RAB8B Is Required for Activity and Caveolar Endocytosis of LRP6
-н: Kubilay Demir, зэрэг
Хэвлэсэн: (2013-09-01)

MiR-1247 targets cartilage master regulator SOX9 in human articular cartilage
-н: Martinez-Sanchez, A, зэрэг
Хэвлэсэн: (2013)

Endocytic pathways of TIMP-3 and its N-terminal inhibitory domain
-н: Scilabra, S, зэрэг
Хэвлэсэн: (2009)

Basic fibroblast growth factor: An extracellular mechanotransducer in articular cartilage?
-н: Vincent, T, зэрэг
Хэвлэсэн: (2006)

Basic fibroblast growth factor: an extracellular mechanotransducer in articular cartilage?
-н: Vincent, T, зэрэг
Хэвлэсэн: (2006)

Increased TIMP-3 expression alters the cellular secretome through dual inhibition of the metalloprotease ADAM10 and ligand-binding of the LRP-1 receptor
-н: Scilabra, SD, зэрэг
Хэвлэсэн: (2018)

Articular cartilage /
-н: Athanasiou, K. A. (Kyriacos A.)
Хэвлэсэн: (c201)

ARTICULAR CARTILAGE /
-н: Athanasiou, K. A. (Kyriacos A.), author, зэрэг
Хэвлэсэн: (2017)

Hypoxia. HIF-mediated articular chondrocyte function: prospects for cartilage repair.
-н: Murphy, C, зэрэг
Хэвлэсэн: (2009)

What makes the permanent articular cartilage permanent?
-н: Murphy, C
Хэвлэсэн: (2011)

Engineering and expression of ADAMTS-4 and ADAMTS-5, proteolytic enzymes involved in osteoarthritis progression
-н: Lauer-Fields, J, зэрэг
Хэвлэсэн: (2005)

Promoting endogenous articular cartilage regeneration using extracellular matrix scaffolds
-н: David C. Browe, зэрэг
Хэвлэсэн: (2022-12-01)

LRP-1 Promotes Colon Cancer Cell Proliferation in 3D Collagen Matrices by Mediating DDR1 Endocytosis
-н: Cao Cuong Le, зэрэг
Хэвлэсэн: (2020-06-01)

Calcium pentosan polysulfate is a multi-functional aggrecanase inhibitor that enhances interaction with endogenous TIMP-3 in cartilage
-н: Troeberg, L, зэрэг
Хэвлэсэн: (2009)

Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4.
-н: Gendron, C, зэрэг
Хэвлэсэн: (2007)

Suramin inhibits osteoarthritic cartilage degradation by increasing extracellular levels of chondroprotective tissue inhibitor of metalloproteinases 3 (TIMP-3)
-н: Chanalaris, A, зэрэг
Хэвлэсэн: (2017)