LRP-1-mediated endocytosis regulates extracellular activity of ADAMTS-5 in articular cartilage.

Eitemau Tebyg

• Low density lipoprotein receptor-related protein 1 (LRP1)-mediated endocytic clearance of a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4): functional differences of non-catalytic domains of ADAMTS-4 and ADAMTS-5 in LRP1 binding.
  gan: Yamamoto, K, et al.
  Cyhoeddwyd: (2014)
• LRP-dependent and -independent internalisation of TIMP-3
  gan: Scilabra, S, et al.
  Cyhoeddwyd: (2011)
• Inhibition of LRP1 shedding reverses cartilage matrix degradation in osteoarthritis
  gan: Yamamoto, K, et al.
  Cyhoeddwyd: (2017)
• MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1
  gan: Yamamoto, K, et al.
  Cyhoeddwyd: (2016)
• The C-terminal domains of ADAMTS-4 and ADAMTS-5 promote association with N-TIMP-3.
  gan: Troeberg, L, et al.
  Cyhoeddwyd: (2009)