LRP-1-mediated endocytosis regulates extracellular activity of ADAMTS-5 in articular cartilage.
Aggrecan is a major matrix component of articular cartilage, and its degradation is a crucial event in the development of osteoarthritis (OA). Adamalysin-like metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) is a major aggrecan-degrading enzyme in cartilage, but there is no clear correlatio...
主要な著者: | , , , , , , |
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フォーマット: | Journal article |
言語: | English |
出版事項: |
2013
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