Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction.

Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction.

Diabetes, obesity and Alzheimer’s disease (AD) are associated with vascular complications and impaired nitric oxide (NO) production. Furthermore, increased β-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1), APP and β-amyloid (Aβ) are linked with vascular disease development and raised...

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Main Authors: Meakin, PJ, Coull, BM, Tuharska, Z, McCaffery, C, Akoumianakis, I, Antoniades, C, Brown, J, Griffin, KJ, Platt, F, Ozber, CH, Yuldasheva, NY, Makava, N, Skromna, A, Prescott, AR, McNeilly, AD, Siddiqui, MK, Palmer, CNA, Khan, F, Ashford, MLJ
Formato: Journal article
Idioma:English
Publicado: American Society for Clinical Investigation 2020

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