Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP.

Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP.

Бусад хувилбаруудыг харуулах (1)

Mutations in the leucine-rich repeat kinase-2 (LRRK2) gene cause late-onset Parkinson's disease, but its physiological function has remained largely unknown. Here we report that LRRK2 activates a calcium-dependent protein kinase kinase-β (CaMKK-β)/adenosine monophosphate (AMP)-activated protein...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	Gómez-Suaga, P, Luzón-Toro, B, Churamani, D, Zhang, L, Bloor-Young, D, Patel, S, Woodman, P, Churchill, G, Hilfiker, S
Формат:	Journal article
Хэл сонгох:	English
Хэвлэсэн:	2012

Ижил төстэй зүйлс

Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP
-н: Gómez-Suaga, P, зэрэг
Хэвлэсэн: (2012)

A link between LRRK2, autophagy and NAADP-mediated endolysosomal calcium signalling.
-н: Gómez-Suaga, P, зэрэг
Хэвлэсэн: (2012)

NAADP is a Physiologically-Relevant Calcium Mobilising Compound in Atrial Myocytes
-н: Bayliss, R, зэрэг
Хэвлэсэн: (2012)

Parkinson's Disease: Leucine-Rich Repeat Kinase 2 and Autophagy, Intimate Enemies
-н: José M. Bravo-San Pedro, зэрэг
Хэвлэсэн: (2012-01-01)

NAADP-induced calcium release in sea urchin eggs.
-н: Galione, A, зэрэг
Хэвлэсэн: (2000)

Nicotinic acid adenine dinucleotide phosphate (NAADP) regulates autophagy in cultured astrocytes.
-н: Pereira, G, зэрэг
Хэвлэсэн: (2011)

Leucine Rich Repeat Kinase 2 and Innate Immunity
-н: Diba Ahmadi Rastegar, зэрэг
Хэвлэсэн: (2020-03-01)

Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway
-н: Tong Youren, зэрэг
Хэвлэсэн: (2012-01-01)

Role of leucine-rich repeat kinase 2 in severe acute pancreatitis
-н: Yasuo Otsuka, зэрэг
Хэвлэсэн: (2024-02-01)

Structure and regulation of full-length human leucine-rich repeat kinase 1
-н: Riley D. Metcalfe, зэрэг
Хэвлэсэн: (2023-08-01)

Calcium signalling by nicotinic acid adenine dinucleotide phosphate (NAADP).
-н: Yamasaki, M, зэрэг
Хэвлэсэн: (2005)

Coordination of Ca2+ signalling by NAADP.
-н: Patel, S, зэрэг
Хэвлэсэн: (2001)

Unique kinetics of nicotinic acid-adenine dinucleotide phosphate (NAADP) binding enhance the sensitivity of NAADP receptors for their ligand.
-н: Patel, S, зэрэг
Хэвлэсэн: (2000)

Leucine-Rich Repeat Kinase 2 Mutations and Parkinson's Disease: Three Questions
-н: Elisa Greggio, зэрэг
Хэвлэсэн: (2009-03-01)

Effect of leucine-rich repeat kinase 2 (LRRK2) on protein synthesis
-н: Hyejung Kim, зэрэг
Хэвлэсэн: (2018-01-01)

Leucine-rich repeat kinase-2 deficiency protected against cardiac remodelling in mice via regulating autophagy formation and degradation
-н: Yuan Liu, зэрэг
Хэвлэсэн: (2022-03-01)

Effects of NAADP on contraction and calcium transients in guinea-pig isolated ventricular myocytes
-н: Macgregor, A, зэрэг
Хэвлэсэн: (2005)

Leucine-rich repeat kinase 2 functionally interacts with microtubules and kinase-dependently modulates cell migration
-н: Mareike Caesar, зэрэг
Хэвлэсэн: (2013-06-01)

Identification and characterization of a leucine-rich repeat kinase 2 (LRRK2) consensus phosphorylation motif.
-н: Pooja P Pungaliya, зэрэг
Хэвлэсэн: (2010-10-01)

Leucine-Rich Repeat Kinase-2 Controls the Differentiation and Maturation of Oligodendrocytes in Mice and Zebrafish
-н: Alice Filippini, зэрэг
Хэвлэсэн: (2024-07-01)

Cell-autonomous role of leucine-rich repeat kinase in the protection of dopaminergic neuron survival
-н: Jongkyun Kang, зэрэг
Хэвлэсэн: (2024-06-01)

Leucine-Rich Repeat Kinase 2-Linked Parkinson’s Disease: Clinical and Molecular Findings
-н: Udhaya Kumari, зэрэг
Хэвлэсэн: (2010-10-01)

The Double-Faceted Role of Leucine-Rich Repeat Kinase 2 in the Immunopathogenesis of Parkinson’s Disease
-н: Mengfei Zhang, зэрэг
Хэвлэсэн: (2022-05-01)

NAADP influences excitation-contraction coupling by releasing calcium from lysosomes in atrial myocytes.
-н: Collins, T, зэрэг
Хэвлэсэн: (2011)

NAADP influences excitation-contraction coupling by releasing calcium from lysosomes in atrial myocytes
-н: Collins, T, зэрэг
Хэвлэсэн: (2011)

NAADP influences excitation-contraction coupling by releasing calcium from lysosomes in atrial myocytes
-н: Collins, T, зэрэг
Хэвлэсэн: (2011)

NAADP mediates ATP-induced Ca2+ signals in astrocytes.
-н: Barceló-Torns, M, зэрэг
Хэвлэсэн: (2011)

Loss of leucine-rich repeat kinase 2 (LRRK2) in rats leads to progressive abnormal phenotypes in peripheral organs.
-н: Marco A S Baptista, зэрэг
Хэвлэсэн: (2013-01-01)

Investigating voice as a biomarker for leucine-rich repeat kinase 2-associated Parkinson’s disease
-н: Arora, S, зэрэг
Хэвлэсэн: (2018)

CLERC and centrosomal leucine-rich repeat proteins
-н: Muto Yoshinori, зэрэг
Хэвлэсэн: (2010-02-01)

Leucine-rich repeat kinase 2 controls protein kinase A activation state through phosphodiesterase 4
-н: Isabella Russo, зэрэг
Хэвлэсэн: (2018-10-01)

Leucine Repeat Rich Kinase 1 Controls Osteoclast Activity by Managing Lysosomal Trafficking and Secretion
-н: Sandi Shen, зэрэг
Хэвлэсэн: (2023-03-01)

Leucine-rich repeat kinase 2 and alpha-synuclein: intersecting pathways in the pathogenesis of Parkinson's disease?
-н: Civiero Laura, зэрэг
Хэвлэсэн: (2011-01-01)

Corrigendum: New Insights on Leucine-Rich Repeats Receptor-Like Kinase Orthologous Relationships in Angiosperms
-н: Jean-François Dufayard, зэрэг
Хэвлэсэн: (2017-05-01)

Synthesis, degradation, binding and actions of NAADP in cardiac tissue.
-н: Rakovic, S, зэрэг
Хэвлэсэн: (2001)

Cardiac L-type calcium channel regulation by Leucine-Rich Repeat-Containing Protein 10
-н: Natthaphat Siri-Angkul, зэрэг
Хэвлэсэн: (2024-12-01)

NAADP receptors mediate calcium signaling stimulated by endothelin-1 and norepinephrine in renal afferent arterioles.
-н: Thai, T, зэрэг
Хэвлэсэн: (2009)

Calcium stimulates the synthesis of nicotinic acid adenine dinucleotide phosphate (NAADP) in sea urchin sperm
-н: Lewis, A, зэрэг
Хэвлэсэн: (2005)

Acidic NAADP-sensitive calcium stores in the endothelium: agonist-specific recruitment and role in regulating blood pressure.
-н: Brailoiu, G, зэрэг
Хэвлэсэн: (2010)

Structure-aware annotation of leucine-rich repeat domains.
-н: Boyan Xu, зэрэг
Хэвлэсэн: (2024-11-01)