Chromothripsis orchestrates leukemic transformation in blast phase MPN through targetable amplification of DYRK1A
Chromothripsis, the process of catastrophic shattering and haphazard repair of chromosomes, is a common event in cancer. Whether chromothripsis might constitute an actionable molecular event amenable to therapeutic targeting remains an open question. We describe recurrent chromothripsis of chromosom...
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Format: | Internet publication |
Language: | English |
Published: |
2023
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