Chromothripsis orchestrates leukemic transformation in blast phase MPN through targetable amplification of DYRK1A

Chromothripsis orchestrates leukemic transformation in blast phase MPN through targetable amplification of DYRK1A

Chromothripsis, the process of catastrophic shattering and haphazard repair of chromosomes, is a common event in cancer. Whether chromothripsis might constitute an actionable molecular event amenable to therapeutic targeting remains an open question. We describe recurrent chromothripsis of chromosom...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Brierley, CK, Yip, BH, Orlando, G, Goyal, H, Wen, S, Wen, J, Levine, MF, Jakobsdottir, GM, Rodriguez-Meira, A, Adamo, A, Bashton, M, Hamblin, A, Clark, SA, O'Sullivan, J, Murphy, L, Olijnik, AA, Cotton, A, Narina, S, Pruett-Miller, SM, Enshaei, A, Harrison, C, Drummond, M, Knapper, S, Tefferi, A, Antony-Debré, I, Thongjuea, S, Wedge, DC, Constantinescu, S, Papaemmanuil, E, Psaila, B, Crispino, JD, Mead, AJ
Format: Internet publication
Sprache:English
Veröffentlicht: 2023

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