The role of plasma and vascular tetrahydrobiopterin in vascular disease states
<p>The endothelial nitric oxide synthase (eNOS) co-factor tetrahydrobiopterin (BH4) has been shown to play a pivotal role in maintaining endothelial function in experimental vascular disease models. In BH4-deficient states, eNOS becomes enzymatically ‘uncoupled’, generating reactive oxygen spe...
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| Format: | Thesis |
| Language: | English |
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2011
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