A Multi-Crystal Method for Extracting Obscured Crystallographic States from Conventionally Uninterpretable Electron Density

In macromolecular crystallography, the rigorous detection of changed states (for example, ligand binding) is difficult unless signal is strong. Ambiguous (‘weak’ or ‘noisy’) density is experimentally common, since molecular states are generally only fractionally present in the crystal. Existing meth...

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Autors principals: Pearce, N, Krojer, T, Bradley, A, Collins, P, Nowak, R, Talon, R, Marsden, B, Kelm, S, Shi, J, Deane, C, von Delft, F
Format: Journal article
Publicat: Springer Nature 2017