Accurately reflecting uncertainty when using patient-level simulation models to extrapolate clinical trial data

<p><strong>Introduction:</strong> Patient-level simulation models facilitate extrapolation of clinical trial data while allowing for heterogeneity, prior history, and nonlinearity. However, combining different types of uncertainty around within-trial and extrapolated results remain...

Full description

Bibliographic Details
Main Authors: Dakin, H, Leal, J, Briggs, A, Clarke, P, Holman, R, Gray, A
Format: Journal article
Language:English
Published: SAGE Publications 2020