On the diastereoselectivity of alkylations of bicyclic lactams
The diastereoselectivity in the alkylation of the enolates of bicyclic lactams 2 derived from pyroglutaminol 1a has been found to depend upon the nature of the hemiaminal ether protecting group. Although exo-alkylation has been widely reported for 2a,b,e, endo-alkylation is favoured for 2d. It is po...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2000
|