Fold recognition and alignment in the ‘twilight zone’

Fold recognition and alignment in the ‘twilight zone’

<p>At present, the most accurate approach to predicting protein structure, comparative modelling, builds a model of a target sequence using known protein structures as templates. Comparative modelling becomes markedly less accurate in the ‘twilight zone’, where the target protein shares little...

Fuld beskrivelse

Bibliografiske detaljer
Main Authors:	Hill, J, Jamie Hill
Andre forfattere:	Deane, C
Format:	Thesis
Sprog:	English
Udgivet:	2013
Fag:	Bioinformatics (life sciences) Bioinformatics (biochemistry) Protein folding Membrane proteins Mathematical genetics and bioinformatics (statistics)

Lignende værker

Protein fold evolution on completed genomes: distinguishing between young and old folds
af: Abeln, S, et al.
Udgivet: (2007)

Exploring the fold space preferences of ancient and newborn protein superfamilies
af: Edwards, H, et al.
Udgivet: (2014)

Protein loop structure prediction
af: Choi, Y
Udgivet: (2011)

NucleoFinder: a statistical approach for the detection of nucleosome positions
af: Becker, J, et al.
Udgivet: (2013)

Computational studies of protein helix kinks
af: Wilman, H, et al.
Udgivet: (2014)

MicroRNA expression and activity in high-grade serous ovarian cancer
af: Howe, EA
Udgivet: (2012)

An integrated genomic approach for the identification and analysis of single nucleotide polymorphisms that affect cancer in humans
af: Repapi, E
Udgivet: (2013)

The estimation of recombination rates from population genetic data
af: Auton, A
Udgivet: (2007)

Statistical challenges in the detection of mutation and variation using high throughput sequencing
af: Pfeifer, S
Udgivet: (2012)

Computational studies of protein dynamics and dynamic similarity
af: Munz, M
Udgivet: (2012)

Multiple sequence analysis in the presence of alignment uncertainty
af: Herman, J, et al.
Udgivet: (2014)

GAT: a simulation framework for testing the association of genomic intervals
af: Heger, A, et al.
Udgivet: (2013)

A novel domain suggests a ciliary function for ASPM, a brain size determining gene
af: Ponting, C
Udgivet: (2006)

Application of the Neutral Indel Model to genome sequences for diverse metazoans
af: Meader, S
Udgivet: (2010)

A method for the identification of biological pathways
af: Honti, F
Udgivet: (2014)

Gene x gene interactions in genome wide association studies
af: Bhattacharya, K
Udgivet: (2014)

Understanding lineage-specific biology through comparative genomics
af: Li, Y
Udgivet: (2014)

Protocol for generating protein profiles and distance-based network analysis of murine tissue slices
af: Luisa Schmidt, et al.
Udgivet: (2025-03-01)

Identification of homologous protein models via 3D comparisons using predicted structures
af: Anyu Pan, et al.
Udgivet: (2024-03-01)

Design and analysis of genome-wide association studies
af: Barrett, J
Udgivet: (2008)

Large-scale genetic analysis of quantitative traits
af: Randall, J, et al.
Udgivet: (2012)

Cotranslational protein folding - fact or fiction?
af: Deane, C, et al.
Udgivet: (2007)

Bayesian methods for fine mapping in genetic association studies
af: Frangou, E
Udgivet: (2013)

Probabilistic models of RNA secondary structure
af: Anderson, JWJ
Udgivet: (2013)

Comparative analysis of derived mutations across human populations.
af: Feder, A, et al.
Udgivet: (2013)

Statistical methods for mapping complex traits
af: Allchin, L
Udgivet: (2014)

Statistical methods for the analysis of genetic association studies
af: Su, Z
Udgivet: (2008)

LD-based SNP and genotype calling from next-generation sequencing reads.
af: Menelaou, A
Udgivet: (2012)

Statistical methods for genotype microarray data on large cohorts of individuals
af: O'Connell, JM
Udgivet: (2014)

The detection, structure and uses of extended haplotype identity in population genetic data
af: Xifara, DK
Udgivet: (2014)

Genome annotation and selectional analysis of viral evolution
af: de Groot, S
Udgivet: (2008)

Application of String Kernel on protein sequence classification /
af: Nazar Mustafa Zaki, et al.
Udgivet: (2003)

Protein bioinformatics : an algorithmic approach to sequence and structure analysis /
af: 391358 Eidhammer, Ingvar, et al.
Udgivet: (2004)

From protein structure to function with bioinformatics /
af: Rigden, Daniel John
Udgivet: (2009)

On genetic variants underlying common disease
af: Hechter, E
Udgivet: (2011)

Modelling sequential protein folding under kinetic control
af: Huard, F, et al.
Udgivet: (2006)

Role of mutual information for predicting contact residues in proteins
af: Gomes, M
Udgivet: (2012)

Structural modelling of transmembrane domains
af: Kelm, S
Udgivet: (2011)

Modelling and comparing protein interaction networks using subgraph counts
af: Chegancas Rito, TM
Udgivet: (2012)

Comparative neurotranscriptomics in mammals and birds
af: Belgard, TG
Udgivet: (2011)