Lethal osteogenesis imperfecta and a collagen gene deletion. Length polymorphism provides an alternative explanation.
A 300 base pair deletion near the 3'-end of the gene encoding Type II (cartilage) collagen has been implicated in the pathogenesis of perinatal lethal osteogenesis imperfecta. We have found similar deletions occurring at a high frequency in normal Asian Indian and West Indian populations genera...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1985
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