Statins and selective inhibition of Rho kinase protect small conductance calcium-activated potassium channel function (K(Ca)2.3) in cerebral arteries

Background In rat middle cerebral and mesenteric arteries the KCa2.3 component of endothelium-dependent hyperpolarization (EDH) is lost following stimulation of thromboxane (TP) receptors, an effect that may contribute to the endothelial dysfunction associated with cardiovascular disease. In cerebra...

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Detalhes bibliográficos
Main Authors: McNeish, A, Jimenez-Altayo, F, Cottrell, G, Garland, C
Formato: Journal article
Idioma:English
Publicado em: Public Library of Science 2012