Systems model of T cell receptor proximal signaling reveals emergent ultrasensitivity

Systems model of T cell receptor proximal signaling reveals emergent ultrasensitivity

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Receptor phosphorylation is thought to be tightly regulated because phosphorylated receptors initiate signaling cascades leading to cellular activation. The T cell antigen receptor (TCR) on the surface of T cells is phosphorylated by the kinase Lck and dephosphorylated by the phosphatase CD45 on mul...

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Egile Nagusiak: Mukhopadhyay, H, Cordoba, S, Maini, P, Van Der Merwe, P, Dushek, O
Formatua: Journal article
Hizkuntza:English
Argitaratua: Public Library of Science 2013
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