Hypoxia inhibits MHC I expression and antigen presentation to escape immune surveillance
Hypoxia is a common feature of solid tumors that has previously been linked to resistance to radiotherapy and chemotherapy, and more recently to immunotherapy. In particular, hypoxic tumors exclude T cells and inhibit their activity, suggesting that tumor cells acquire a mechanism to evade T cell re...
Hlavní autoři: | Estephan, H, Tailor, A, Parker, R, Kreamer, M, Papandreou, I, Campo, L, Easton, A, Moon, EJ, Denko, N, Ternette, N, Hammond, E, Giaccia, A |
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Médium: | Journal article |
Jazyk: | English |
Vydáno: |
EMBO Press
2025
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