A tick protein with a modified Kunitz fold inhibits human tryptase.
TdPI, a tick salivary gland product related to Kunitz/BPTI proteins is a potent inhibitor of human beta-tryptase. Kinetic assays suggest that three of the four catalytic sites of tryptase are blocked by TdPI, and that the inhibition of one of these involves a peptide flanking the Kunitz head. In the...
| Главные авторы: | , , , , , |
|---|---|
| Формат: | Journal article |
| Язык: | English |
| Опубликовано: |
2007
|