RASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p73.

Transition from pluripotency to differentiation is a pivotal yet poorly understood developmental step. Here, we show that the tumour suppressor RASSF1A is a key player driving the early specification of cell fate. RASSF1A acts as a natural barrier to stem cell self-renewal and iPS cell generation, b...

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Bibliografiske detaljer
Main Authors:	Papaspyropoulos, A, Bradley, L, Thapa, A, Leung, C, Toskas, K, Koennig, D, Pefani, D, Raso, C, Grou, C, Hamilton, G, Vlahov, N, Grawenda, A, Haider, S, Chauhan, J, Buti, L, Kanapin, A, Lu, X, Buffa, F, Dianov, G, von Kriegsheim, A, Matallanas, D, Samsonova, A, Zernicka-Goetz, M, O'Neill, E
Format:	Journal article
Sprog:	English
Udgivet:	Nature Publishing Group 2018

RASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p73.

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