Appraising the relevance of DNA copy number loss and gain in prostate cancer using whole genome DNA sequence data

A variety of models have been proposed to explain regions of recurrent somatic copy number alteration (SCNA) in human cancer. Our study employs Whole Genome DNA Sequence (WGS) data from tumor samples (n = 103) to comprehensively assess the role of the Knudson two hit genetic model in SCNA generation...

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Bibliographic Details
Main Authors:	Camacho, N, Van Loo, P, Edwards, S, Kay, J, Matthews, L, Haase, K, Clark, J, Dennis, N, Thomas, S, Kremeyer, B, Zamora, J, Butler, A, Gundem, G, Merson, S, Luxton, H, Hawkins, S, Ghori, M, Marsden, L, Lambert, A, Karaszi, K, Pelvender, G, Massie, C, Kote-Jarai, Z, Raine, K, Jones, D, Howat, W, Hazell, S, Livni, N, Fisher, C, Ogden, C, Kumar, P, Thompson, A, Nicol, D, Mayer, E, Dudderidge, T, Yu, Y, Zhang, H, Shah, N, Gnanapragasam, V, Isaacs, W, Visakorpi, T, Hamdy, F, Berney, D, Verrill, C, Warren, A, Wedge, D, Lynch, A, Foster, C, Lu, Y, Bova, G, Whitaker, H, McDermott, U, Neal, D, Eeles, R, Cooper, C, Brewer, D
Other Authors:	Beroukhim, R
Format:	Journal article
Language:	English
Published:	Public Library of Science 2017

Appraising the relevance of DNA copy number loss and gain in prostate cancer using whole genome DNA sequence data

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