Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission
Alpha synuclein aggregation plays a central role in Parkinson's disease pathology. Direct transmission of alpha synuclein from pathologically affected to healthy unaffected neurons may be important in the anatomical spread of the disease through the nervous system. We have demonstrated that exo...
| Главные авторы: | , , , , , , |
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| Формат: | Journal article |
| Язык: | English |
| Опубликовано: |
Elsevier
2011
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| Предметы: |