A phylogenetic codon substitution model for antibody lineages
Phylogenetic methods have shown promise in understanding the development ofbroadly neutralizing antibody lineages (bNAbs). However, the mutational process that generates these lineages – somatic hypermutation (SHM) – is biased by hotspot motifs, which violates important assumptions in most phylogene...
| Main Authors: | , , |
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| Format: | Journal article |
| Published: |
Genetics Society of America
2017
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